The world watches while the population of Gaza – nearly half of which are children – endure an unprecedented humanitarian catastrophe. Starvation and disease are rampant due to the lack of food and aid. Bombs continue to fall, destroying homes and killing and injuring civilians. Children and young people are among the most exposed to violence, deprivation, and inequalities in this war. This is even more true for children without, or at risk of losing, parental care. Thousands of children have been killed, and tens of thousands have lost one or both parents. In addition to their own trauma, they feel the struggles and fears of the adults caring for them and their loved ones. The human, humanitarian and psychological consequences on all children and families from Gaza will be substantial and long-lasting.